Ajit Koti

at the intersection of distributed systems, agent infrastructure, and early-stage investing

Research

Side projects using AlphaFold to study how disease-causing mutations reshape proteins.

Structures from AlphaFold Protein Structure Database and AlphaFold Server.

Neurodegeneration

Parkinson's Variant ExplorerExplores how Parkinson's-associated mutations in SNCA, LRRK2, PINK1 and PARK7 alter protein structure. Compares wild-type and mutant folds, quantifies the deviation by RMSD, renders both in an interactive py3Dmol viewer, and pairs each variant with an LLM agent that summarizes the relevant PubMed literature. Streamlit app, containerized.

Nephrology

ADPKD Variant ExplorerExamines pathogenic PKD1 and PKD2 variants behind autosomal dominant polycystic kidney disease against AlphaFold-predicted structures. Pulls variant data from ClinVar and the PKD Mutation Database and renders the mutations in an interactive 3D viewer.